In both scenarios, the recommendations are as follows: (following 1 : 1 dose transfer from basal insulin) divide the total daily dose into two equal doses; give half before breakfast, the other half before dinner; titrate to goal based on self-monitored blood glucose data and diet history; the largest meal will require a larger proportion of insulin; reduce the total dose by 20% if the patient experiences recurrent hypoglycaemia. This evidence concerns the gene INS and Hypoglycemia.