PPARGC1A and hypertrophic cardiomyopathy: Since PGC-1α related pathways can be directly regulated by Myc [18], we suspect that Myc-mediated PGC-1α regulation, which is tightly related with mitochondrial biogenesis and function, is a key pathway for the development of hypertrophic cardiomyopathy and heart failure in MHC-Myc mice [19], [20].