MYC and cardiomyopathy: To circumvent both of these problems and to study the importance of Myc-driven cell cycle re-entry in the pathogenesis of cardiomyopathy, we used a tetracycline-controlled system to generate bitransgenic mice (MHC-Myc) that inducibly overexpress Myc under the control of the αMHC gene promoter that drives high transgene expression specifically in cardiomyocytes [21].