Protein expression data from ‘The Human Protein Atlas’ (http://www.proteinatlas.org/) bioinformatics tool was available for RNF41 and MKK3. This data provided evidence for the up-regulation of RNF41 in B-CLL, since immunohistochemistry analysis demonstrated weak-moderated expression of RNF41 in B-CLL samples, while peripheral blood mononuclear cells from healthy blood donors showed negative-weak expression of the protein. This evidence concerns the gene MAP2K3 and B-cell chronic lymphocytic leukemia.