Of these 5 differentially expressed genes, 2 (BAZ2A and RNF41) were up-regulated (Figure 2) and 3 (RASSF5, MKK3, and LRIG1) were down-regulated (Figure 3) in CLL patients with low levels of MIR-15a/16-1 expression. This evidence concerns the gene RASSF5 and B-cell chronic lymphocytic leukemia.