CFH and age-related macular degeneration: One such example is an SNP in the complement factor H gene (rs1061170) which has a large effect size with age-related macular degeneration in Caucasians [33],[43],[44] but much smaller in East Asian populations due to a remarkably lower risk allele frequency (∼35% in Caucasians and ∼5% in East Asians) [45].