But on the other hand we could not establish an independent predictor (e.g. tumor histology, tumor grade, tumor size, estrogen receptor content, progesterone receptor content, Her-2 over expression, age of the patients, bilateral disease or the lymph node status) for women with suspect breast lesions for whom the method of CNB and frozen section analysis could not be recommended. The gene discussed is ERBB2; the disease is neoplasm.