In univariate analysis the investigated tumor characteristics, i.e. tumor histology (p = 0.4), tumor grade (p = 0.5), tumor size (p = 0.4), estrogen receptor content (p = 0.3), progesterone receptor content (p = 0.3) and Her-2 over expression (p = 0.6) did not influence the accuracy of frozen section analysis of the CNB. Here, ESR1 is linked to neoplasm.