scrib- + RasACT tumour cells grow out basally from the eye disc, fail to differentiate (Figure 5A, B) and appear to invade the brain lobes along F-actin rich cables extending from between the eye/antennal disc to the brain, eventually leading to a fusion between the eye discs, brain lobes and surrounding tissues (see Additional file 4, panels A-D). This evidence concerns the gene SCRIB and neoplasm.