Proteins involved in both cell migration and invasion, including the matrix metalloproteinase, Mmp1 (data not shown) [16,18] and the integrin-associated scaffolding protein, Paxillin (Pax), were up-regulated in scrib mutant clones and at the invasive front of scrib- + RasACT tumours, in a JNK-dependent manner (see Additional file 5). The gene discussed is MMP1; the disease is neoplasm.