Infiltration into sinusoids and into intrahepatic veins, resulting in luminal narrowing and obliteration with polypoidal projections, are characteristic features of hepatic EHE.[2, 3, 6] Demonstration of the vascular or endothelial origin of the tumor is critical for diagnosis and requires immunostaining for endothelial markers, including factor VIII-related antigen, CD31, and CD34.[6, 10] Surgical resection or orthotopic liver transplantation is considered the treatment of choice, though rarely radiotherapy and chemotherapy may be used in patients with associated metastases.[3–5]. Here, PECAM1 is linked to neoplasm.