TP53 and breast carcinoma: Although one postulated mechanism for a dominant effect of mutant p53 is through the inhibition of p63 and/or p73 (Di Como et al, 1999; Strano et al, 2000; Gaiddon et al, 2001), the apoptosis induced by mutant p53 knockdown in breast cancer cells is independent of the p63 or p73 function.