It should be mentioned that genes coding for ECM and for proteins involved in ECM remodelling: collagen 1 (COLI), collagen III (COLIII), lumican (LUM), laminin-β1 (LAMB1), metallomatrixproteinase 2 (MMP2), CTSK, connective tissue growth factor (CTGF), SPARC and OSF2 were characteristic for the NS cHL (Table 3). This evidence concerns the gene SPARC and classic Hodgkin lymphoma.