FZD7 and malignant colon neoplasm: Moreover, the down-regulation of FZD7 with Small-interfering RNA (siRNA) in colon cancer cells resulted in decreased in vitro invasion activity (Ueno et al, 2008), which is consistent with previous findings that inhibition of FZD7 expression with dominant-negative mutant construct or siRNA reduced the motility of hepatocellular carcinoma cells (Merle et al, 2004) or colon cancer cells (Vincan et al, 2007), respectively.