It was shown that inhibitors of the canonical signalling, Dickkopf (DKK)-1 and a dominant-negative Tcf construct, did not reduce Wnt3a-dependent motility of CHO-K1 cells (Endo et al, 2005), and that DKK-1 and DKK-2 had no effect on Wnt3a-induced migration of myeloma cells (Weeraratna et al, 2002). The gene discussed is HNF4A; the disease is plasma cell myeloma.