MKI67 and neoplasm: The significant independent predictors for reduced RFS were stage III (hazard ratio (HR) 4.00, 95% confidence interval (CI) 2.50–6.39), high histological tumour grade (HR 1.80, 95% CI 1.09–2.98), whereas a high Ki-67 expression (⩾40%) was independently associated with an improved RFS (HR 0.55, 95% CI 0.34–0.89).