TNF-α antibody could neutralize the quantity of TNF-α, and anti-TNFR antibody could block the combination between TNF-α and TNF-α R. When TNF-α was blockaded with anti-TNF-α IgG antibody or anti-TNF-α R1 antibody, there was a significant decrease in the mice of liver failure and no bacterial invasion or hepatocyte necrosis. The gene discussed is TNFRSF1A; the disease is liver failure.