Five additional genes with significantly altered probeset expression in LCLs between schizophrenia and unaffected relatives (ADCY1, DSC2, DSC3, GLS and PDE4D) were examined by qPCR expression in DLPFC tissue from subjects with schizophrenia and non-psychotic controls in cohort 3. The gene discussed is PDE4D; the disease is schizophrenia.