AAK1 and early-onset autosomal dominant Alzheimer disease: Aside from the identification of the AAK1 gene near 2p13, the strongest association result observed under one of the previously reported linkage regions occurs near the gene sortilin-related VPS10 domain containing receptor 3 (SORCS3) located near the LOD score peak at 10q, originally identified in a combined linkage scan of onset age in PD and Alzheimer's disease [70].