In addition, targeted disruption of the Trps1 gene in the mouse causes craniofacial abnormalities, kyphoscoliosis and reduced trabecular bone in heterozygous mice, and a lack of vibrissae, scoliosis and abnormalities in the thoracic spine and ribs in homozygous mice [12]. Here, TRPS1 is linked to Kyphoscoliosis.