The increase in plasma prolactin levels is associated with D2 receptor antagonism.[11] Elevated levels of prolactin in females cause menstrual disturbances and galactorrhoea[12, 13] and have been linked with disturbed sexual function in terms of desire, erections, orgasm in females and may even cause hypogonadism.[14, 15] A case report is being highlighted having hyperprolactinaemia with a low dosage of the novel antipsychotic drug amisulpride. This evidence concerns the gene PRL and hypogonadism.