This can be attributed to the disturbance in the overall mechanism of generation of free radicals and their consequent neutralization due to oxidative stress in schizophrenia, where SOD is utilized for neutralizing the free radical superoxide ion (O2.-) to H2 O2 and oxygen, and GSHPx reduces this H2 O2 to water.[20] Schizophrenia also seems to disturb the glutathione homeostasis, which is also one of the factors responsible for weakening the antioxidant defense provided by enzymatic antioxidants.[3, 21]. Here, SOD1 is linked to schizophrenia.