Unexpectedly, tumors from scirrhous carcinoma clones, i.e. clones showing low levels of BMP-6 mRNA expression in vitro (see Figure 1) and a low degree of Smad-1/5 pathway activation (see Figure 2G-I), were strongly positive for BMP-6 protein (Figure 5E-F). This evidence concerns the gene BMP6 and carcinoma.