Further, the only clone derived from the osteosarcoma not being able to form tumors in vivo (clone 3) expressed very high levels of BMPs (BMP-2, -4, -5, -6) in vitro, thus further supporting the notion that the BMP expression profile of the inoculated clones is not a major determinant for tumorigenicity. The gene discussed is CLN5; the disease is osteosarcoma.