Mice lacking RhoB alone do not show any signs of myelodysplasia or any developmental or fertility defects, but Ras-transformed mouse embryonic fibroblasts (MEFs) from these mice are resistant to apoptosis in the presence of farnesyltransferase inhibitors (FTIs), doxorubicin, or taxol [14], [15], [16]. Here, RHOB is linked to Myelodysplasia.