Based on the documented association of LPA with TDP-43 pathology (Mesulam et al., 2008) the phenotypic range of GRN mutations might also include LPA-like syndromes, however the true nosological place of LPA within the PPA spectrum and the core features of the LPA syndrome and the aphasic syndrome(s) that accompany GRN mutations have not been clarified. The gene discussed is LPA; the disease is primary progressive aphasia.