Unless validation of the SPP1 transcript or osteopontin protein from cows harbouring allele C or T SPP1c.-1251C>T is performed (haplotypes H2 and H5 contained an abolished SP1 binding site [Table 6]) the veracity of the tangible impact of SPP1c.-1251C>T on bacterial infection remains unknown. Here, SPP1 is linked to bacterial infectious disease.