A functional cross-talk between cPLA2-α and sPLA2-IIA in IL-induced RA SF cells, such as that observed in other cell types [51-53], may signify the importance of sPLA2 relative to cPLA2 induction in cytokine-stimulated RA SF cells and its inhibition by PIP-18 for RA treatment. The gene discussed is PLA2G4A; the disease is rheumatoid arthritis.