SIPA1 and breast carcinoma: As a previous study showed that SIPA1 RNAi down-regulation increased the primary tumour burden in the mouse model, and given the previous observations that the Sipa1 gene and protein are associated with poor-prognosis markers and metastasis, we considered the possibility that the SIPA1 gene may be correlated to breast carcinoma incidence as well as prognosis.