Furthermore, the other two SNPs of SIPA1 screened; rs931127 which is a 5' near gene SNP and rs746429 which is a synonymous (Ala (A) to Ala (A)) SNP, did not show significant association with breast cancer, yet were reported to be associated with lymph node metastasis in the previous study. The gene discussed is SIPA1; the disease is breast cancer.