We sought to establish if blockade of VEGFR1 activity could eradicate tumor progression to metastasis in a model mirroring the neoadjuvant and adjuvant therapy of tumors (i.e., continuous VEGFR1 blockade in mice from the time of implantation of the primary tumor, including the period after resection of the primary tumor when it has reached 1 cm in diameter and has seeded metastatic cells in the lungs). Here, FLT1 is linked to neoplasm.