[17]). Control and treatment groups were compared using student's t-tests and rank-sum tests (Mann-Whitney U), and differences in metastatic tumor formation were not significant between groups. Thus, genetic ablation of VEGFR1 activity did not result in significantly different rate of formation of macroscopic lung metastasis. Similarly, the number of spontaneous macroscopic lung metastases formed 2 weeks after LLC1 or B16 resection was not significantly different between flt-1TK–/–/C57BL and C57BL mice [17]. Here, FLT1 is linked to neoplasm.