PARK7 and brain ischemia: In addition, aconitase inactivation has been observed in various animal and cell models of neuronal disorders and oxidative stress [32], [33] including excitotoxicity [17], cerebral ischemia [34], beta-amyloid toxicity [35], oxygen-glucose deprivation [30], MPTP toxicity [16], Sod2 and DJ1 mutant mice [18], [36], [37] as well as in aging [38], [39].