Furthermore, from age 4 to 8 weeks, percent fractional shortening decreased more rapidly in DBA.AKR-Hrtfm2/Csqtg mice (36%, p = 0.0004) than the littermates (18%, p = 0.186), suggesting that the presence of even a single AKR-Hrtfm2 locus (essentially half the normal AKR/B6 level of TNNI3K expression) can accelerate the progression of the Csq-induced cardiomyopathy. Here, TNNI3K is linked to cardiomyopathy.