These 23 ESGs genes are highly co-expressed with epigenetic genes and also highly differentially expressed in distinct ALL phenotypes groups (CBX1, CBX5, CBX6, CBX7, PHLDA2, BAZ2A, BAZ2B, MYST2, MYST4, MECP2, SMARCA2, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC9, SMARCA4, SMYD3, SUV39H1, DNMT3A, DNMT3B, PRDM2 and MBD2). This evidence concerns the gene MBD2 and acute lymphoblastic leukemia.