The genes ABCG4, ARNT2, BCOR, CABP2, CSTF2, DNTTIP1, FGG, IGF2BP1, MAL2, MMP11, RBM16, TM4SF1, ZBTB4, ZNF394 are involved in connective tissue disorders and inflammatory disease, which are prerequisite to TAA. Here, SCAF8 is linked to connective tissue disorder.