In conclusion, while some of the alterations induced by Dbl oncogene expression in mouse lenses resemble in part those described for certain types of cataracts, the extent of the abnormalities, the modulation of certain genes and the block of the apoptotic pathway together with the induction of lymphangiogenesis and vascularization in the lens suggest that the expression of onco Dbl in epithelial cells may cause changes that cannot be merely ascribed to a fibrotic process. This evidence concerns the gene MCF2 and cataract.