It encompasses MDM4. This gene has not been implicated in BL, but MDM4 inhibits P53, and in vivo development of B-cell lymphomas in Eμ-myc MDM4+/− mice is delayed compared to that occurring in Eμ-myc MDM4+/+ mice [37]. This evidence concerns the gene MDM4 and B-cell non-Hodgkin lymphoma.