To assess the general significance of the findings in the RT2 insulinoma model as well as to test whether the observed integration of BMDC occurred also in the absence of transgenic expression of VEGF-C, we employed the TRAMP-C1 murine prostate adenocarcinoma cell line previously shown to induce robust tumor lymphangiogenesis upon transplantation into syngeneic C57Bl/6 mice [27], [28]. The gene discussed is VEGFC; the disease is prostate adenocarcinoma.