This point is supported by a recent study by Uno et al. who showed that induction of tumor cell apoptosis by an agonistic antibody to TRAILR2/DR5, combined with T cell activation by CD40 and 4-1BB agonistic monoclonal antibodies, potently and rapidly stimulated tumor-specific CD8+ T cells capable of eradicating pre-established tumors [65]. This evidence concerns the gene TNFRSF9 and neoplasm.