Like p524-expanded CD4+CD25+ T cells, p570-expanded CD4+CD25+ T cells actively inhibited diabetes transfer to NOD.scid mice (Figure 10a), and the transfer of 1×106 p570-stimulated CD4+CD25+ T cells was sufficient to prevent overt autoimmunity in young NOD mice (Figure 10b). The gene discussed is CD4; the disease is diabetes mellitus.