CD4 and diabetes mellitus: Again, our data indicated that p570-expanded CD4+CD25+ T cell-mediated protective effects in two models were partially due to IL-10/TGF-β secretion of these cells as blockade of IL-10/TGF-β activities in vivo dramatically abrogated the prevention from diabetes development which was mediated by p570-expanded CD4+CD25+ T cells (Figure 10a and b).