TP53 and cancer: Consequently, therehave been many efforts to find small molecule drugs that mimic the cancer rescueeffect of reactivating p53 and suppressing tumor growth [19]–[24].Despite some promising discoveries in p53 in specific, and small moleculedocking in general, these efforts are hampered by a limited understanding of thep53 mutation-structure-function relationship [11], [25]–[28].