In vivo assaysshowed that the predicted Positive Region: (1) had significantly more(p<0.01) new strong cancer rescue mutants than control regions (Negative,and non-MIP active learning); (2) had slightly more new strong cancer rescuemutants than an Expert region selected for purely biological considerations; and(3) rescued for the first time the previously unrescuable p53 cancer mutantP152L. Here, TP53 is linked to cancer.