TAMs also possess poor antigen presenting ability and effectively suppress the induction of proper anti-tumor T cell response through the production of immunosuppressive cytokines like TGF-β and IL-10 [6], [10], as well as promote induction and infiltration of CD4+CD25+FoxP3+ T cells (Treg) at the tumor site [11]. The gene discussed is CD4; the disease is neoplasm.