When stratifying with plasma VEGF level, the median PFS times for the three groups were 58, 27 and 17 months, respectively (log-rank test, P=0.005), whereas median RCC-SS time was not reached for the first two groups and was 36 months for the third group (log-rank test, P=0.003; Figure 5A). The gene discussed is VEGFA; the disease is renal cell carcinoma.