Although LRH-1 is transcriptionally regulated by ER (Annicotte et al, 2005) and is stimulated by co-activators, such as the peroxisome-proliferator-activated receptor γ co-activator-1α (PGC-1α), to execute its function (Safi et al, 2005), little is known about the regulation of LRH-1 and PGC-1α in breast tumour tissue during aromatase inhibition. Here, PPARGC1A is linked to breast neoplasm.