In contrast, some CK8/18-expressing adenocarcinomas show downregulation of such expression with progression, which correlates with poor outcome, as reported in human breast cancer (Takei et al, 1995; Schaller et al, 1996; Woelfle et al, 2004) and colorectal cancer (Knosel et al, 2006). The gene discussed is KRT8; the disease is adenocarcinoma.