To investigate the reported anti-apoptotic effect of dyskerin (Yoon et al, 2006) in prostate cancer cells, Du145 or 22Rv1 cells pretreated with siRNA for 3 days were challenged with apoptosis inducers TNF-α or tunicamycin (Shiraishi et al, 2005). The gene discussed is DKC1; the disease is prostate carcinoma.