EIF2A and ductal breast carcinoma in situ: Thus, these structures that resemble DCIS can be forced into a more differentiated or normal architecture by enhancing eIF2α phosphorylation Salubrinal did not affect the levels of BimEL, a pro-apoptotic protein implicated in lumen formation [7] (data not shown) indicating that apoptosis might proceed via selective activation of other pro-apoptotic phospho-eIF2α targets or via autophagic death [35].