CYP1B1 and open-angle glaucoma: Mutations in the CYP1B1 gene cause an autosomal recessive form of primary congenital glaucoma [28] and two common sequence variants (Val432Leu and Asn453Ser) in the CYP1B1 gene are proposed to act as a risk factor for the development of POAG [29] and to influence clinical features like optic disk cupping and visual field deterioration in POAG patients [30].