CFH and age-related macular degeneration: A total of four AMD risk loci have been identified with convincing statistical evidence, including the complement factor H gene (CFH) on chromosome 1q32 [12-17], the ARMS2/HTRA1 locus on 10q26 [18-23], the complement component 3 gene on 19p13 [24-28], and two neighboring genes on 6p21: complement factor B, and complement component 2 [29-32].