Identifying the functions of lipin-1 sumoylation in brain (e.g. which genes are transcriptionally controlled by this mechanism and whether this is linked to neuron survival or differentiation) and revealing its physiological and pathological relevance (e.g. whether this is involved in regulation of learning and memory and/or implicated in neuropathy) represent important challenges in future studies. Here, LPIN1 is linked to neuropathy.