RXRA and renal cell adenocarcinoma: Across the RXRA gene (Figure 2), a single region located downstream, 3′ of the coding sequence, was shown to be associated with increased RCC risk among individuals with the CG (OR = 1.35; 95% CI = 1.11–1.66; p-value = 0.003) haplotype compared to subjects with the most common haplotype, GA. The R adjusted global p-value for this region was 0.03.