However, given the limited genomic coverage of VDR in our previous candidate SNP investigation, and the numerous genes that interact directly with VDR in the vitamin D pathway, we expanded upon these findings to investigate variation in candidate genes that may interact directly with VDR to modify RCC risk and improved our analysis by increasing regional coverage of variation across each gene to 80–90%. The gene discussed is VDR; the disease is renal cell adenocarcinoma.