In the present study, we provide clinical evidence in support of up-regulation of Wnt/β-catenin signaling in invasive ductal carcinoma of breast and key components of this signaling pathway such as E-cadherin, Slug, GSK3β and β-catenin to be associated with Epithelial Mesenchymal Transition (EMT) process and pathogenesis of IDCs. The gene discussed is GSK3B; the disease is invasive ductal breast carcinoma.