It has recently been shown that genetic and epigenetic alterations of some candidate cancer genes (CAN genes) including; SYNE1, MMP2, GPNMB, APC2, EVL, PTPRD, CDH5, LGR6, STARD8, CD109, ICAM5, CHD5, RNF, and RET, are important in the progression of CRC [10], [11]. This evidence concerns the gene GPNMB and cancer.