Of the 767 genes analyzed only six genes (0.8%) were commonly hypermethylated in HNs (Figure 4A), namely DBC1, DIO3, FZD9, HS3ST2, MOS and MYOD1. In contrast, the vast majority of the genes being hypermethylated in T-cell lymphomas were also found becoming hypermethylated in B-cell lymphomas (92 genes corresponding to 85% of all hypermethylated genes). The gene discussed is DIO3; the disease is B-cell non-Hodgkin lymphoma.