NPC1 and Tremor: Npc1−/− mice treated with a combination therapy of NB-DNJ (administered daily starting at P10) and allopregnanolone/CD (administered weekly starting at P7) showed a 2 week delay in onset of clinical signs (ataxic gait, tremor) when compared to untreated (given no injections) or vehicle (saline or CD) treated Npc1−/− mice.