Ferritin light chain is also upregulated in circulating leukocytes of patients with juvenile rheumatoid arthritis, sickle cell disease, autoimmune renal disease or multiple sclerosis, indicating that altered FTL gene expression in peripheral cells of CAD patients might in at least in part reflect a general pro-inflammatory state that leads to degenerative changes [49]–[52]. Here, FTL is linked to sickle cell disease.