Interestingly, four of these genes (KCNMB1, NEDD4L, ADD1 and NPR3) have been implied in genetic susceptibility for hypertension [41]–[44], while two genes have been associated with genetic susceptibility for stroke (PDE4D) [45] or myocardial infarction (ADD1) [46]. The gene discussed is PDE4D; the disease is hypertensive disorder.