Studies have indicated that OPG, given either at the onset of hypercalcemia or after it had occurred (hypercalcemia over 3-5 days), blocks tumor-induced bone resorption and hypercalcemia and therefore leads to normalization of blood calcium within 48 hours [43-45] suggesting an effective method for curing this paraneoplasmatic syndrome. The gene discussed is TNFRSF11B; the disease is hypercalcemia disease.